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MOTIVATE increases device-measured moderate-to-vigorous physical activity (MVPA) at 3 and 6 months among community-dwelling stroke survivors compared with general PA information.

The MOTIVATE trial is a hybrid type 1 effectiveness-implementation randomized controlled trial testing a theory-informed, co-designed behavior change intervention to increase physical activity after stroke. The primary outcome is average daily minutes of moderate-to-vigorous physical activity (MVPA) measured by Fitbit Inspire 3 at 3 and 6 months. The trial aims to recruit 120 participants to detect a 10-minute/day difference in MVPA with 80% power, allowing for 20% attrition.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Multi-mOdal training program to promote physical actIVity after sTrokE (MOTIVATE): Protocol for effectiveness and economic outcomes in a hybrid type 1 effectiveness-implementation randomised controlled trial.

observational

Thilarajah S, Hao PY, De Silva DA, Thumboo J, Leng LL, Hollis J, Bird ML, Clark RA, Wang J, Kaur P, Khim KL · Contemporary clinical trials (2026)

Participants: N/A
Duration: 6 months follow-up
Intervention: MOTIVATE: a multi-modal, theory-informed, co-designed behavior change intervention to promote physical activity after stroke.
Outcome: Average daily minutes of moderate-to-vigorous physical activity (MVPA) measured by Fitbit Inspire 3 at 3 and 6 months.
Effect Size: N/A (protocol paper; target difference is 10 min/day MVPA)
Population: Community-dwelling stroke survivors aged ≥21 years, ≥6 months post-stroke, ambulant with or without an aid.

Result:

PubMed: 42632450DOI: 10.1016/j.cct.2026.108441

Mechanism Graph

MOTIVATE intervention delivered to stroke survivors
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Behavior change techniques target self-efficacy, fatigue, mood, and sleep
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Increased motivation and capability to engage in physical activity
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Increased daily MVPA at 3 and 6 months

Limitations

  • ⚠Protocol paper; results not yet available, so effectiveness is not confirmed.
  • ⚠Primary outcome relies on Fitbit device, which may have measurement error or adherence issues.
  • ⚠Sample size calculation assumes 20% attrition, which may affect power if attrition is higher.

Frequently Asked Questions

What is the MOTIVATE intervention?▼

MOTIVATE is a theory-informed, co-designed behavior change intervention to promote physical activity after stroke, delivered to community-dwelling stroke survivors.

How is physical activity measured in the MOTIVATE trial?▼

Physical activity is measured using a Fitbit Inspire 3 device, which records daily minutes of moderate-to-vigorous physical activity (MVPA).

Who is eligible for the MOTIVATE trial?▼

Adults aged 21 years or older, at least 6 months post-stroke, living at home, and able to walk with or without an aid.

What is the primary outcome of the MOTIVATE trial?▼

The primary outcome is the average daily minutes of moderate-to-vigorous physical activity (MVPA) at 3 and 6 months post-randomization.

Products

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References

  1. 1.Thilarajah S, Hao PY, De Silva DA, Thumboo J, Leng LL, Hollis J, Bird ML, Clark RA, Wang J, Kaur P, Khim KL. "Multi-mOdal training program to promote physical actIVity after sTrokE (MOTIVATE): Protocol for effectiveness and economic outcomes in a hybrid type 1 effectiveness-implementation randomised controlled trial.." Contemporary clinical trials, 2026. PMID: 42632450 DOI: 10.1016/j.cct.2026.108441
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.