1242 sleep evidence claims,
each scored for scientific confidence
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Representative claims people are checking:
Tart cherry juice (240ml twice daily) increases total sleep time by approximately 84 minutes and improves sleep efficiency in older adults with insomnia. The effect is attributed to natural melatonin content and procyanidins.
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All topics →Ambien, Xanax, Lunesta… and the natural stacks people use instead
Side-by-side comparisons for "[drug] + natural alternative" searches.
Trending Evidence
View all →Melatonin reduces sleep onset latency by approximately 7 minutes in adults with primary sleep disorders
A comprehensive meta-analysis of 19 RCTs (1,683 participants) found melatonin reduces sleep latency by ~7 minutes and increases total sleep time by ~8 minutes. Effects are more pronounced in older adults and those with circadian rhythm disruptions.
Low-dose melatonin (0.5mg) effectively shifts circadian rhythm for jet lag, shift work, and delayed sleep phase syndrome
Melatonin is the most potent chronobiotic available. Administered 5 hours before dim-light melatonin onset (DLMO), even low doses (0.5mg) produce a 1-2 hour phase advance. This makes it effective for jet lag, shift work adaptation, and delayed sleep phase syndrome. Timing is more critical than dose.
Glycine reduces sleep latency in human RCTs
Glycine (3g before bed) significantly reduces sleep onset latency and improves subjective sleep quality in healthy adults. Evidence from 3 human RCTs shows consistent effects, with the mechanism involving NMDA receptor modulation and thermoregulation.
Moderate-intensity aerobic exercise (150 min/week) significantly improves sleep quality in adults with chronic insomnia
A 4-week RCT found 150 min/week of moderate aerobic exercise significantly improved PSQI scores and objective sleep measures in adults with chronic insomnia. Exercise is recommended as a first-line behavioral intervention for insomnia.
Glycine improves overall sleep quality and reduces daytime sleepiness
Beyond reducing sleep latency, glycine (3g before bed) improves PSG-measured sleep quality including increased REM sleep and reduced nocturnal awakenings. Daytime sleepiness and fatigue are also significantly reduced the following morning.
Ashwagandha root extract (300mg BID) significantly improves sleep quality and reduces sleep onset latency in adults with insomnia
A well-designed 8-week RCT (n=138) found ashwagandha root extract significantly improved PSQI scores, reduced sleep onset latency, and improved sleep efficiency. Benefits were most pronounced in adults with insomnia and anxiety.
Fresh Evidence
Recently added, highest-rated claims
Milk-derived bioactives and fortified or fermented milk products improve sleep efficiency in randomized controlled trials.
A systematic review and meta-analysis of 11 RCTs found that milk-derived bioactives and fortified or fermented milk products significantly improved sleep efficiency (SMD = 0.45; 95% CI, 0.21-0.70). Subgroup analyses showed greater improvements in sleep efficiency (SMD = 0.52) and wake after sleep onset (MD = -8.24 minutes) in individuals with sleep or health disturbances, and reduced sleep latency in healthy participants (MD = -2.17 minutes).
Moderate physical activity is associated with a modest reduction in insomnia risk, while occupational physical activity may increase insomnia risk
This meta-analysis of 27 observational studies found that moderate physical activity was associated with a 7% lower risk of insomnia (OR=0.93, 95% CI 0.87-1.00), while high physical activity showed no significant association (OR=0.96, 95% CI 0.85-1.09). Occupational physical activity was associated with a 21% higher risk of insomnia (OR=1.21, 95% CI 1.02-1.43). The findings suggest that the intensity and domain of physical activity matter for sleep health.
Nurses' sleep duration and quality have declined significantly over recent decades
A meta-regression of 280 studies involving 219,245 nurses found a significant decline of 28.7 minutes in sleep duration between 1985 and 2022 (95% CI: 26.2, 33.1, ES: 0.43) and a 1.6-point increase in global PSQI scores between 1990 and 2023, indicating poorer sleep quality (95% CI: 1.47, 1.77, ES: 0.49). These trends suggest an increased risk of fatigue, impaired clinical performance, staff burnout, and work-related accidents.
Variable-rate feedback infusion reduces cumulative opioid consumption at 48 hours postoperatively compared with fixed-rate basal infusion in patients undergoing mixed surgery
This protocol describes a prospective, multicentre, randomised, double-blind, controlled trial to compare cumulative opioid consumption at 48 hours postoperatively between variable-rate feedback infusion and fixed-rate basal infusion modes of intravenous patient-controlled analgesia (PCA). The study will enrol 1170 patients undergoing mixed surgery and will measure total cumulative opioid consumption as the primary outcome, with secondary outcomes including pain scores and quality of recovery. The hypothesis is that variable-rate feedback infusion reduces opioid consumption while providing non-inferior analgesia.
LTC-022 (Lactium and L-theanine) improves sleep maintenance and bedtime regularity in adults with sleep discomfort
In a double-blind, placebo-controlled RCT of 40 adults with sleep discomfort, 8 weeks of LTC-022 supplementation did not significantly improve PSQI or ISI scores compared to placebo. However, sleep diary analysis showed significant reductions in wake after sleep onset (WASO) counts and earlier bedtime in the LTC-022 group, along with within-group improvements in total sleep time, sleep onset latency, and sleep efficiency. Gut microbiome analysis revealed increased abundance of Blautia and Ruminococcus genera in the LTC-022 group.
Brief CBT-I improves insomnia symptoms in women receiving chemotherapy for breast cancer
In a randomized clinical trial of 219 women undergoing chemotherapy for breast cancer, 6 weeks of CBT-I significantly reduced insomnia symptoms (ISI score MD, -2.19 [95% CI, -3.33 to -1.05]; P=.002) compared to non-CBT-I groups. However, CBT-I did not significantly improve fatigue symptoms (PROMIS-Fatigue MD, -0.90 [95% CI, -3.08 to 1.28]; P=.52). Bright light therapy (BLT) did not significantly improve either insomnia or fatigue symptoms compared to non-BLT groups.
Evidence Explorer
661 claimsThe Integrated Resilience Method improves chronic low back pain management in women over 50
The Integrated Resilience Method is a six-pillar framework for postmenopausal women with chronic low back pain, integrating exercise, pain education, and self-efficacy as core components with the strongest evidence. It addresses biopsychosocial factors including hormonal change, sarcopenia, sleep disruption, fear-avoidance, and caregiving stress.
Circadian disruption is closely associated with Alzheimer's disease pathology and therapeutic response, supporting chronotherapeutic strategies.
This narrative review synthesizes evidence that circadian dysfunction contributes to Alzheimer's disease pathogenesis through interactions between core clock genes and neurodegenerative cascades involving oxidative stress, neuroinflammation, glial reactivity, and proteostasis. Emerging evidence suggests distinct circadian patterns in AD-relevant biomarkers, including melatonin, cortisol, orexin, core body temperature, blood-brain barrier permeability, and glial marker oscillations, which may have diagnostic and prognostic relevance.
Exploding head syndrome is associated with reduced sleep quality and altered sleep architecture, including lower total sleep time, sleep efficiency, and REM percentage, and higher sleep latency, wakefulness after sleep onset, N1 percentage, and PSQI score.
In a retrospective study of 26 EHS patients and 22 controls, PSG data from 16 patients showed significantly lower total sleep time (p=0.001), sleep efficiency (p<0.001), and REM percentage (p=0.019), and significantly higher sleep latency (p=0.001), wakefulness after sleep onset (p=0.001), N1 percentage (p=0.010), and PSQI score (p=0.016). Additionally, 96% of patients reported stress and 84% had difficulty falling asleep.
Circadian disruption and dysregulated BMAL1 signaling impair oocyte quality and may negatively impact assisted reproduction outcomes
The paper reviews evidence that BMAL1, a core circadian transcription factor, regulates ovarian physiology including folliculogenesis, steroidogenesis, mitochondrial activity, oxidative balance, and meiotic spindle organization. Dysregulated BMAL1 signaling is associated with compromised oocyte quality and early embryo development, and clinical findings suggest circadian disruption, sleep problems, obesity, ageing, and metabolic dysfunction may influence IVF outcomes.
A standardized multicomponent respiratory guidance and nursing care protocol improves sleep quality in elderly patients with COPD
This paper describes a 12-week multicomponent intervention integrating breathing training, respiratory muscle training, aerobic exercise, and continuous nursing support based on Orem's self-care deficit theory. Sleep quality measurement is included as a standardized outcome, but no numerical results are reported in the abstract.
AI and chatbot-supported interventions for pediatric physical activity and obesity-related lifestyle behaviors show mixed effectiveness, with 4 of 8 studies reporting significant improvements in physical activity or fitness outcomes.
This scoping review of 14 studies found that AI-enabled chatbot interventions for pediatric physical activity and obesity-related behaviors are a rapidly emerging field, with most studies published since 2023. Among 8 studies reporting direct physical activity or fitness outcomes, 4 showed significant improvement, 2 found no significant change, and 2 reported mixed or indirect findings. Family involvement was present in 71.4% of studies, and feasibility and acceptability were generally favorable.
Sport-related activities may facilitate post-disaster mental health recovery through physiological regulation, psychological empowerment, and social reconnection.
This narrative review of 11 studies proposes that sport-related activities (participatory and spectator-based) can aid mental health recovery after natural disasters by modulating the HPA axis, restoring self-efficacy, and rebuilding social networks. The evidence is observational and heterogeneous, so causal effects cannot be established.
Patients after ACL reconstruction perceive significant sleep disturbances leading to poor sleep quality, which negatively impacts health outcomes in the early postoperative phase.
This qualitative study of 12 participants aged 18-35 years, 1-3 months post-ACLR, found that patients perceived significant sleep disturbances and poor sleep quality, which they believed negatively affected their physical recovery and psychological functioning. Three major themes emerged: sleep disturbances, repercussions of sleep disturbances, and prior knowledge of sleep hygiene.
Urban Indian young adults perceive adequate sleep as a component of a healthy lifestyle.
In a qualitative study of 79 urban Indian young adults (aged 21-30) from eight metropolitan cities, participants identified adequate sleep as one of three key perceptions of a healthy lifestyle, alongside consuming a balanced diet and leading an active life. The study used in-depth interviews and thematic analysis to explore barriers and facilitators of a healthy lifestyle.
Chronic sleep deprivation and circadian disruption flatten cortisol circadian patterns and alter ultradian glucocorticoid pulsatility
This narrative review synthesizes evidence that chronic exposure to sleep deprivation and circadian disruption alters HPA axis function, leading to flattened daily cortisol rhythms and disrupted ultradian glucocorticoid pulsatility. These changes are associated with allostatic load and psychological/metabolic maladaptation.
Children under 3 years with feeding disorders have inadequate nutrient intake in quantity and quality
This study of 40 children under 3 years with feeding disorders found that average daily energy intake was below recommended values, with 62.5% of children in the insufficient intake range. Micronutrient deficiencies were observed for vitamin B6, vitamin D, calcium, magnesium, iron, and zinc, while vitamin K intake was excessive.
Physical activity improves mental well-being in esports practitioners through improved sleep quality and reduced cognitive fatigue
Physical activity (PA) positively predicted mental well-being in esports players, serially mediated by improved sleep quality and reduced cognitive fatigue. SHAP analysis revealed a non-linear dose-response pattern, with the steepest benefits at 600-1,200 MET-min/week and plateauing beyond approximately 1,800 MET-min/week.
Newest Studies
All →Comparison of cumulative opioid consumption between variable-rate feedback infusion and fixed-rate basal infusion modes of intravenous patient-controlled analgesia following mixed surgery: protocol for a prospective randomised controlled trial.
BMJ open, 2026 · observational
Five-year patient-reported outcomes of individualized nutrition therapy supporting nutritional ketosis in adults with type 2 diabetes.
Frontiers in nutrition, 2026 · observational
Associations of actigraphic sleep parameters with adipokines in older adults in the Baltimore longitudinal study of aging.
Sleep advances : a journal of the Sleep Research Society, 2026 · observational
The Impact of Milk-Derived Bioactives and Fortified or Fermented Milk Products on Sleep Quality: A Systematic Review and Meta-Analysis.
Nutrition reviews, 2026 · observational
Recently Updated
All →Insomnia induces intestinal microbiota disorder, and artificial interventions targeting gut microbiota can improve sleep.
This narrative review summarizes evidence that insomnia can disrupt intestinal microbiota by activating immune responses, the HPA axis, and neuroendocrine systems, while gut microbiota can exacerbate insomnia via neurotransmitter and inflammatory factor release. Artificial interventions such as probiotics, traditional Chinese medicine, fecal microbiota transplantation, diet, and exercise may improve sleep by affecting neurotransmitter and microbial metabolite release.
Melissa officinalis Phytosome (MOP) improves sleep quality in adults with mild insomnia
In a double-blind, placebo-controlled crossover study, MOP significantly reduced Insomnia Severity Index (ISI) scores by an average of 2.9 points compared to placebo (6.8 ± 4.1 vs 9.7 ± 3.7, p=0.003). Slow-wave sleep (SWS) duration increased by 15%, REM sleep decreased by 10%, and 87% of treated participants reported improved sleep quality versus 30% in the placebo group (χ²=21.01, p=0.0003).
Gut microbiota taxa are causally associated with insomnia risk in European ancestry individuals
A Mendelian randomization study identified that Enterorhabdus, Family XIII AD3011 group, Paraprevotella, and Lachnospiraceae UCG004 increase insomnia risk, while Coprococcus1, Coprobacter, Desulfovibrio, Flavonifractor, Olsenella, Odoribacter, and Oscillibacter decrease risk. For specific insomnia phenotypes, Eisenbergiella increased risk of trouble falling asleep, while Haemophilus and Eubacterium brachy group reduced it; Family XIII UCG001, Lachnospiraceae FCS020 group, and Olsenella increased risk of waking too early, while Eubacterium brachy group and Victivallis reduced it.
Six hub herb pairs (Radix Astragali-Radix et Rhizoma Ginseng, Rhizoma Chuanxiong-Radix Glycyrrhizae, Seman Platycladi-Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae-Radix Glycyrrhizae, Radix Polygalae-Semen Ziziphi Spinosae, Radix Astragali-Semen Ziziphi Spinosae) may treat insomnia via the cAMP signaling pathway synergistically with HIF-1, prolactin, chemical carcinogenesis receptor activation, and PI3K-Akt signaling pathways.
This study analyzed 104 TCM prescriptions for insomnia using data mining, network pharmacology, and molecular docking. Six hub herb pairs were identified, and network pharmacology suggested they may act through the cAMP signaling pathway in synergy with four other pathways, with molecular docking showing good binding affinity between active ingredients and hub targets.
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