1202 sleep evidence claims,
each scored for scientific confidence
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Representative claims people are checking:
Tart cherry juice (240ml twice daily) increases total sleep time by approximately 84 minutes and improves sleep efficiency in older adults with insomnia. The effect is attributed to natural melatonin content and procyanidins.
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All topics →Ambien, Xanax, Lunesta… and the natural stacks people use instead
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Trending Evidence
View all →Melatonin reduces sleep onset latency by approximately 7 minutes in adults with primary sleep disorders
A comprehensive meta-analysis of 19 RCTs (1,683 participants) found melatonin reduces sleep latency by ~7 minutes and increases total sleep time by ~8 minutes. Effects are more pronounced in older adults and those with circadian rhythm disruptions.
Low-dose melatonin (0.5mg) effectively shifts circadian rhythm for jet lag, shift work, and delayed sleep phase syndrome
Melatonin is the most potent chronobiotic available. Administered 5 hours before dim-light melatonin onset (DLMO), even low doses (0.5mg) produce a 1-2 hour phase advance. This makes it effective for jet lag, shift work adaptation, and delayed sleep phase syndrome. Timing is more critical than dose.
Glycine reduces sleep latency in human RCTs
Glycine (3g before bed) significantly reduces sleep onset latency and improves subjective sleep quality in healthy adults. Evidence from 3 human RCTs shows consistent effects, with the mechanism involving NMDA receptor modulation and thermoregulation.
Moderate-intensity aerobic exercise (150 min/week) significantly improves sleep quality in adults with chronic insomnia
A 4-week RCT found 150 min/week of moderate aerobic exercise significantly improved PSQI scores and objective sleep measures in adults with chronic insomnia. Exercise is recommended as a first-line behavioral intervention for insomnia.
Glycine improves overall sleep quality and reduces daytime sleepiness
Beyond reducing sleep latency, glycine (3g before bed) improves PSG-measured sleep quality including increased REM sleep and reduced nocturnal awakenings. Daytime sleepiness and fatigue are also significantly reduced the following morning.
Ashwagandha root extract (300mg BID) significantly improves sleep quality and reduces sleep onset latency in adults with insomnia
A well-designed 8-week RCT (n=138) found ashwagandha root extract significantly improved PSQI scores, reduced sleep onset latency, and improved sleep efficiency. Benefits were most pronounced in adults with insomnia and anxiety.
Fresh Evidence
Recently added, highest-rated claims
NIV may confer greater short-term clinical benefit in children with severe acute asthma requiring respiratory support
In a systematic review and meta-analysis of pediatric asthma exacerbations, non-invasive ventilation (NIV) showed the greatest improvement in asthma scores compared to oxygen (MD = 1.24, p = 0.07), reaching significance in sensitivity analysis (MD = 2.5, p < 0.001). High-flow nasal cannula (HFNC) showed no significant benefit over oxygen (MD = 0.24, p = 0.58) and was associated with higher failure rates compared to NIV (12.6% vs. 2.6%, OR = 5.3, p < 0.001).
CPAP therapy improves surrogate, intermediate, and functional cardiovascular outcomes in adults with obstructive sleep apnea, particularly blood pressure, left ventricular function, and sympathetic activity.
This umbrella review of 38 systematic reviews and meta-analyses found that CPAP therapy was associated with significant reductions in systolic blood pressure (MD -4.8 mmHg) and diastolic blood pressure (MD -3.0 mmHg), improvements in left ventricular ejection fraction (MD 3.27) and diastolic function (WMD 0.22), and reduced sympathetic activity (noradrenaline SMD -1.10). However, the certainty of evidence ranged from low to moderate, and no consistent reduction in major adverse cardiovascular events or mortality was demonstrated.
Single-use negative pressure wound therapy (PICO 7) is a safe and feasible alternative to conventional care for chronic lower limb wounds, with favorable trends in wound area reduction but no statistically significant between-group difference.
In a randomized controlled trial of 31 patients with chronic lower limb wounds, the PICO 7 group showed a higher mean percentage reduction in wound size compared to usual care, but the difference was not statistically significant. No infections were recorded in the PICO 7 group, and quality of life and physical activity remained stable in the intervention group while declining in the control group. A significant negative correlation was found between final wound size and hours of sleep, suggesting wound reduction facilitates better rest.
LCR35 supplementation does not significantly improve pruritus or sleep outcomes in maintenance hemodialysis patients
In a 12-week randomized, open-label controlled study of 78 maintenance hemodialysis patients, LCR35 supplementation (three sachets daily) showed descriptive improvements in pruritus (5-D Itch Scale) and selected sleep outcomes (PSQI), but none of the baseline-adjusted between-group differences were statistically significant. For example, the 5-D Itch Scale difference was -1.48 (95% CI, -3.64 to 0.68; p = 0.176) and global PSQI difference was -0.80 (95% CI, -2.09 to 0.50; p = 0.225).
Stellate ganglion block may alleviate postherpetic neuralgia by modulating neurovascular function, inhibiting inflammatory responses, and blocking pain transmission pathways, but evidence-based data on its efficacy and safety remain insufficient.
This protocol describes a systematic review and meta-analysis to evaluate the efficacy and safety of stellate ganglion block (SGB) for postherpetic neuralgia (PHN). The study will search multiple databases up to December 31, 2025, and will use standard meta-analytic methods. The abstract notes that current evidence is insufficient and inconsistent, indicating the need for this review.
Adjunctive mindfulness-based cognitive therapy improves short-term sleep quality in late-life depression
In a randomized controlled trial of 60 older adults with late-life depression, adding MBCT to treatment as usual improved subjective sleep quality (PSQI) at 8 weeks (between-group difference in change: -3.80, 95% CI -6.50 to -1.10) and increased stable sleep duration by 0.94 hours (95% CI 0.17 to 1.71) compared to TAU alone. Reduced functional connectivity between the right nucleus accumbens and left amygdala during meditation relative to rest was associated with greater increases in stable sleep duration (r=0.45, p=0.013).
Evidence Explorer
329 claimsEarly home-based pulmonary rehabilitation is feasible and safe for post-hospitalisation exertional hypoxaemia patients, but adding high-flow nasal oxygen reduces adherence.
This pilot feasibility trial found that a 3-week home-based pulmonary rehabilitation program for patients with exertional hypoxaemia after hospital discharge had 67% acceptance and 62% uptake. However, the addition of high-flow nasal oxygen during exercise training was associated with lower program completion (60% vs 89%) and reduced adherence to self-directed sessions.
Ferula asafoetida oleo-gum resin improves sleep quality in individuals with functional dyspepsia symptoms
A 14-day randomized, double-blind, placebo-controlled trial found that 250 mg/day of Ferula asafoetida oleo-gum resin (ASF) significantly improved sleep quality as measured by the Bergen Insomnia Scale (BIS), with a mean change of 10.89 ± 3.23 points (P < .001) compared to placebo. The improvement was observed in 62 participants with functional dyspepsia symptoms.
Mindfulness-based stress reduction reduces nocturnal systolic blood pressure in patients with nocturnal hypertension
In a pilot RCT, MBSR significantly reduced nocturnal systolic BP by approximately 7 mmHg compared to usual care (121.9 vs. 128.6 mmHg, P < 0.001). The study demonstrated feasibility with high recruitment and retention rates, though no significant differences were found in other outcomes.
Stapokibart improves sleep domain scores in patients with chronic rhinosinusitis with nasal polyps
In a post-hoc analysis of the phase 3 CROWNS-2 study, stapokibart significantly improved SNOT-22 Sleep domain scores compared to placebo during the 24-week double-blind period. These improvements were maintained or further improved during the 28-week open-label extension and 8-week safety follow-up.
Home-based, remotely monitored pulmonary rehabilitation increases moderate-to-vigorous physical activity in patients with idiopathic pulmonary fibrosis on antifibrotic therapy
In a randomized controlled trial of 29 patients with IPF, a 12-week home-based, remotely monitored exercise program increased daily moderate-to-vigorous physical activity (MVPA) by 28% in the intervention group, while the control group decreased by 35% (p=0.001 for group*time interaction). The intervention group's improvement of 49±19 min/week was nearly double the minimal clinically important difference for IPF. The program was feasible with 100% completion, 92% adherence, and no adverse events.
Nine months of fluoxetine reduces post-traumatic stress symptoms and pain following traumatic musculoskeletal injury
In a non-blinded RCT, 33 patients receiving fluoxetine for 9 months after traumatic musculoskeletal injury showed a significant decrease in PTSD symptoms (estimate = -0.2, 95% CI: -0.4, -0.0) and pain (estimate = -0.1, 95% CI: -0.1, -0.0) over one year, while 35 patients receiving placebo (calcium) showed no significant change. No significant effects were found on depression, anxiety, or social isolation.
Evening high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) produce similar acute changes in circadian core body temperature mesor and phase in adults with obesity, with a borderline non-significant difference in amplitude change.
In a randomized crossover trial of 9 adult males with obesity, evening HIIT (~30 min at 90% HRR) and MIIT (~50 min at 60% HRR) both produced approximately one-hour phase advances in circadian core body temperature rhythm. The change in circadian temperature amplitude differed in direction between conditions (MIIT -0.01 ± 0.19 °C; HIIT +0.12 ± 0.24 °C) but did not reach statistical significance (p = 0.060, d_z = 0.73).
Automated IVR calls added to SMS reminders reduce missed appointments among high-risk patients
Adding automated interactive voice response (IVR) calls to existing text message reminders reduced no-show rates by 1.7 percentage points (from 11.3% to 9.6%) and increased appointment completion rates by 1.9 percentage points (from 75.9% to 77.8%) among high-risk patients. The intervention had the greatest effect on reducing no-shows in the highest risk quartile and improved equity by increasing completion rates most among Black patients.
Community health education lowers blood pressure and improves self-management in elderly hypertensive patients
In a randomized controlled trial of 200 elderly hypertensive patients, adding community health education to routine nursing significantly reduced systolic and diastolic blood pressure, improved self-care and self-management behaviors, reduced depression and anxiety, improved medication adherence, sleep quality, quality of life, and satisfaction compared to routine nursing alone after 6 months. Both groups improved, but the intervention group showed significantly better outcomes on all measures (p < 0.05).
Yoga Nidra and Music Therapy improve sleep quality and mental well-being in post-COVID-19 hospitalised patients compared to standard care alone
In a three-arm RCT of 90 post-COVID-19 hospitalised patients, both Yoga Nidra and Music Therapy (30 min daily for 30 days) significantly improved PSQI, PROMIS Global Health, and WHO-5 scores at day 15 and day 30 compared to standard care (p < .001). Large effect sizes were observed (partial η² = 0.195-0.795), with Yoga Nidra showing greater improvements in well-being and global health, while Music Therapy had stronger effects on sleep quality.
Adding supervised exercise to ergonomics training does not provide statistically significant additional benefit over ergonomics training alone for pain intensity in construction workers with work-related musculoskeletal disorders.
In a 12-week randomized controlled trial of 52 male construction workers with musculoskeletal complaints, both ergonomics training plus exercise and ergonomics training alone significantly improved pain, fatigue, sleep quality, and symptom burden from baseline. However, the between-group difference in pain intensity was not statistically significant (adjusted difference -0.34, 95% CI -0.99 to 0.32), and no significant incremental effect of added exercise was found on any secondary outcome.
A structured recreational exercise program reduces digital addiction and improves sleep quality in children aged 10-14
An 8-week recreational exercise program (3 sessions per week) significantly reduced digital addiction levels and improved sleep quality in 40 children aged 10-14, with large effect sizes. Improvements were maintained at a 6-week follow-up, while the control group showed no significant changes.
Newest Studies
All →Machine Learning-Based Prediction of Sleep Quality in Patients with Multiple Sclerosis.
Medical sciences (Basel, Switzerland), 2026 · observational
Comparing Respiratory Support Modalities in Pediatric Asthma Exacerbation-A Systematic Review and Meta-Analysis.
Pediatric reports, 2026 · meta
Digital health promotion, prevention and health literacy measures among seafarers and crews on cargo and passenger ships: A scoping review.
PloS one, 2026 · observational
Decreased accumbens-amygdala connectivity is associated with sleep improvement in late-life depression following mindfulness-based cognitive therapy.
Journal of affective disorders, 2026 · rct
Recently Updated
All →Insomnia induces intestinal microbiota disorder, and artificial interventions targeting gut microbiota can improve sleep.
This narrative review summarizes evidence that insomnia can disrupt intestinal microbiota by activating immune responses, the HPA axis, and neuroendocrine systems, while gut microbiota can exacerbate insomnia via neurotransmitter and inflammatory factor release. Artificial interventions such as probiotics, traditional Chinese medicine, fecal microbiota transplantation, diet, and exercise may improve sleep by affecting neurotransmitter and microbial metabolite release.
Melissa officinalis Phytosome (MOP) improves sleep quality in adults with mild insomnia
In a double-blind, placebo-controlled crossover study, MOP significantly reduced Insomnia Severity Index (ISI) scores by an average of 2.9 points compared to placebo (6.8 ± 4.1 vs 9.7 ± 3.7, p=0.003). Slow-wave sleep (SWS) duration increased by 15%, REM sleep decreased by 10%, and 87% of treated participants reported improved sleep quality versus 30% in the placebo group (χ²=21.01, p=0.0003).
Gut microbiota taxa are causally associated with insomnia risk in European ancestry individuals
A Mendelian randomization study identified that Enterorhabdus, Family XIII AD3011 group, Paraprevotella, and Lachnospiraceae UCG004 increase insomnia risk, while Coprococcus1, Coprobacter, Desulfovibrio, Flavonifractor, Olsenella, Odoribacter, and Oscillibacter decrease risk. For specific insomnia phenotypes, Eisenbergiella increased risk of trouble falling asleep, while Haemophilus and Eubacterium brachy group reduced it; Family XIII UCG001, Lachnospiraceae FCS020 group, and Olsenella increased risk of waking too early, while Eubacterium brachy group and Victivallis reduced it.
Six hub herb pairs (Radix Astragali-Radix et Rhizoma Ginseng, Rhizoma Chuanxiong-Radix Glycyrrhizae, Seman Platycladi-Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae-Radix Glycyrrhizae, Radix Polygalae-Semen Ziziphi Spinosae, Radix Astragali-Semen Ziziphi Spinosae) may treat insomnia via the cAMP signaling pathway synergistically with HIF-1, prolactin, chemical carcinogenesis receptor activation, and PI3K-Akt signaling pathways.
This study analyzed 104 TCM prescriptions for insomnia using data mining, network pharmacology, and molecular docking. Six hub herb pairs were identified, and network pharmacology suggested they may act through the cAMP signaling pathway in synergy with four other pathways, with molecular docking showing good binding affinity between active ingredients and hub targets.
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