1202 sleep evidence claims,
each scored for scientific confidence
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Representative claims people are checking:
Tart cherry juice (240ml twice daily) increases total sleep time by approximately 84 minutes and improves sleep efficiency in older adults with insomnia. The effect is attributed to natural melatonin content and procyanidins.
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All topics →Ambien, Xanax, Lunesta… and the natural stacks people use instead
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Trending Evidence
View all →Melatonin reduces sleep onset latency by approximately 7 minutes in adults with primary sleep disorders
A comprehensive meta-analysis of 19 RCTs (1,683 participants) found melatonin reduces sleep latency by ~7 minutes and increases total sleep time by ~8 minutes. Effects are more pronounced in older adults and those with circadian rhythm disruptions.
Low-dose melatonin (0.5mg) effectively shifts circadian rhythm for jet lag, shift work, and delayed sleep phase syndrome
Melatonin is the most potent chronobiotic available. Administered 5 hours before dim-light melatonin onset (DLMO), even low doses (0.5mg) produce a 1-2 hour phase advance. This makes it effective for jet lag, shift work adaptation, and delayed sleep phase syndrome. Timing is more critical than dose.
Glycine reduces sleep latency in human RCTs
Glycine (3g before bed) significantly reduces sleep onset latency and improves subjective sleep quality in healthy adults. Evidence from 3 human RCTs shows consistent effects, with the mechanism involving NMDA receptor modulation and thermoregulation.
Moderate-intensity aerobic exercise (150 min/week) significantly improves sleep quality in adults with chronic insomnia
A 4-week RCT found 150 min/week of moderate aerobic exercise significantly improved PSQI scores and objective sleep measures in adults with chronic insomnia. Exercise is recommended as a first-line behavioral intervention for insomnia.
Glycine improves overall sleep quality and reduces daytime sleepiness
Beyond reducing sleep latency, glycine (3g before bed) improves PSG-measured sleep quality including increased REM sleep and reduced nocturnal awakenings. Daytime sleepiness and fatigue are also significantly reduced the following morning.
Ashwagandha root extract (300mg BID) significantly improves sleep quality and reduces sleep onset latency in adults with insomnia
A well-designed 8-week RCT (n=138) found ashwagandha root extract significantly improved PSQI scores, reduced sleep onset latency, and improved sleep efficiency. Benefits were most pronounced in adults with insomnia and anxiety.
Fresh Evidence
Recently added, highest-rated claims
NIV may confer greater short-term clinical benefit in children with severe acute asthma requiring respiratory support
In a systematic review and meta-analysis of pediatric asthma exacerbations, non-invasive ventilation (NIV) showed the greatest improvement in asthma scores compared to oxygen (MD = 1.24, p = 0.07), reaching significance in sensitivity analysis (MD = 2.5, p < 0.001). High-flow nasal cannula (HFNC) showed no significant benefit over oxygen (MD = 0.24, p = 0.58) and was associated with higher failure rates compared to NIV (12.6% vs. 2.6%, OR = 5.3, p < 0.001).
CPAP therapy improves surrogate, intermediate, and functional cardiovascular outcomes in adults with obstructive sleep apnea, particularly blood pressure, left ventricular function, and sympathetic activity.
This umbrella review of 38 systematic reviews and meta-analyses found that CPAP therapy was associated with significant reductions in systolic blood pressure (MD -4.8 mmHg) and diastolic blood pressure (MD -3.0 mmHg), improvements in left ventricular ejection fraction (MD 3.27) and diastolic function (WMD 0.22), and reduced sympathetic activity (noradrenaline SMD -1.10). However, the certainty of evidence ranged from low to moderate, and no consistent reduction in major adverse cardiovascular events or mortality was demonstrated.
Single-use negative pressure wound therapy (PICO 7) is a safe and feasible alternative to conventional care for chronic lower limb wounds, with favorable trends in wound area reduction but no statistically significant between-group difference.
In a randomized controlled trial of 31 patients with chronic lower limb wounds, the PICO 7 group showed a higher mean percentage reduction in wound size compared to usual care, but the difference was not statistically significant. No infections were recorded in the PICO 7 group, and quality of life and physical activity remained stable in the intervention group while declining in the control group. A significant negative correlation was found between final wound size and hours of sleep, suggesting wound reduction facilitates better rest.
LCR35 supplementation does not significantly improve pruritus or sleep outcomes in maintenance hemodialysis patients
In a 12-week randomized, open-label controlled study of 78 maintenance hemodialysis patients, LCR35 supplementation (three sachets daily) showed descriptive improvements in pruritus (5-D Itch Scale) and selected sleep outcomes (PSQI), but none of the baseline-adjusted between-group differences were statistically significant. For example, the 5-D Itch Scale difference was -1.48 (95% CI, -3.64 to 0.68; p = 0.176) and global PSQI difference was -0.80 (95% CI, -2.09 to 0.50; p = 0.225).
Stellate ganglion block may alleviate postherpetic neuralgia by modulating neurovascular function, inhibiting inflammatory responses, and blocking pain transmission pathways, but evidence-based data on its efficacy and safety remain insufficient.
This protocol describes a systematic review and meta-analysis to evaluate the efficacy and safety of stellate ganglion block (SGB) for postherpetic neuralgia (PHN). The study will search multiple databases up to December 31, 2025, and will use standard meta-analytic methods. The abstract notes that current evidence is insufficient and inconsistent, indicating the need for this review.
Adjunctive mindfulness-based cognitive therapy improves short-term sleep quality in late-life depression
In a randomized controlled trial of 60 older adults with late-life depression, adding MBCT to treatment as usual improved subjective sleep quality (PSQI) at 8 weeks (between-group difference in change: -3.80, 95% CI -6.50 to -1.10) and increased stable sleep duration by 0.94 hours (95% CI 0.17 to 1.71) compared to TAU alone. Reduced functional connectivity between the right nucleus accumbens and left amygdala during meditation relative to rest was associated with greater increases in stable sleep duration (r=0.45, p=0.013).
Evidence Explorer
1000 claimsLCR35 supplementation does not significantly improve pruritus or sleep outcomes in maintenance hemodialysis patients
In a 12-week randomized, open-label controlled study of 78 maintenance hemodialysis patients, LCR35 supplementation (three sachets daily) showed descriptive improvements in pruritus (5-D Itch Scale) and selected sleep outcomes (PSQI), but none of the baseline-adjusted between-group differences were statistically significant. For example, the 5-D Itch Scale difference was -1.48 (95% CI, -3.64 to 0.68; p = 0.176) and global PSQI difference was -0.80 (95% CI, -2.09 to 0.50; p = 0.225).
Physical activity participation is associated with lower obesity risk in male Saudi adolescents
Physically active male Saudi adolescents had significantly lower BMI (23.64 vs. 30.28 kg/m2), waist circumference (85.46 vs. 97.35 cm), and waist-to-height ratio (0.488 vs. 0.562) compared to inactive peers. Obesity prevalence by IOTF criteria was 17.1% in active vs. 51.9% in inactive, and abdominal obesity was 31.4% vs. 72.2%.
Single-use negative pressure wound therapy (PICO 7) is a safe and feasible alternative to conventional care for chronic lower limb wounds, with favorable trends in wound area reduction but no statistically significant between-group difference.
In a randomized controlled trial of 31 patients with chronic lower limb wounds, the PICO 7 group showed a higher mean percentage reduction in wound size compared to usual care, but the difference was not statistically significant. No infections were recorded in the PICO 7 group, and quality of life and physical activity remained stable in the intervention group while declining in the control group. A significant negative correlation was found between final wound size and hours of sleep, suggesting wound reduction facilitates better rest.
Transcranial alternating current stimulation (tACS) reduces pain intensity in adults with musculoskeletal pain but does not significantly improve sleep quality.
A meta-analysis of 6 RCTs (232 participants) found that tACS significantly reduced pain intensity compared to control (SMD = -0.355, 95% CI: -0.625 to -0.084, p = 0.010). However, no significant improvement was found for sleep quality (SMD = 0.004, 95% CI: -0.310 to 0.317, p = 0.982). The certainty of evidence was low for both outcomes.
Self-acupressure reduces pain and improves sleep quality in patients with osteoarthritis
A systematic review and meta-analysis of 23 studies (2639 participants) found that self-acupressure was associated with significant reductions in pain (VAS at week 1: SMD = -0.52; WOMAC pain at week 4: SMD = -0.39) and improved sleep quality (PSQI at week 8: SMD = -0.86). The intervention also improved health-related quality of life (SF-6D at week 8: SMD = 0.17). Adverse events were minor and transient, but evidence quality was low-to-moderate with heterogeneity and risk of bias concerns.
Once-daily sustained-release pregabalin (YHD1119) achieves quality of life outcomes comparable to twice-daily immediate-release pregabalin in patients with peripheral neuropathic pain
In a phase 3 randomized, double-blind, active-controlled trial, 296 Korean patients with peripheral neuropathic pain received either once-daily sustained-release pregabalin (YHD1119) or twice-daily immediate-release pregabalin for 12 weeks. Quality of life measures (SF-12, WSIS, PGIC, CGIC) showed no statistically significant differences between groups, with SF-12 Physical Component Summary changes of +2.50 vs +3.08 (p=0.5243) and WSIS improvements of -2.12 vs -2.19 (p=0.3691). The results support the new SR formulation as a practical alternative with comparable patient-reported benefit and once-daily dosing convenience.
Melatonin adjunctive to stable pharmacotherapy improves parent-reported sleep disturbances and Stroop Color-Word Test performance in pediatric ADHD over 6 weeks, though causal attribution is limited by the open-label single-arm design.
In 32 children and adolescents with ADHD and comorbid sleep disturbances on stable methylphenidate or atomoxetine, adjunctive melatonin (3-5 mg/day) for 6 weeks reduced Children's Sleep Habits Questionnaire (CSHQ) total scores from 50.25 ± 3.60 to 34.31 ± 2.69 (F=506.238, p < .001, partial η²=0.942). Stroop Color-Word Test scores showed large observed changes (d=1.12-1.19, all p < .001), but practice effects cannot be excluded without a control group.
Adults with obstructive sleep apnea syndrome appear more likely to experience sleep bruxism, suggesting a potential bidirectional association
An umbrella review of eight systematic reviews found frequent coexistence of sleep bruxism and obstructive sleep apnea syndrome (OSAS) in adults, possibly due to shared mechanisms like micro-arousals and autonomic activation. Only one review included a meta-analysis, and most reviews had low or critically low methodological quality. The evidence is heterogeneous and limited, with causality remaining unclear.
Refugee and asylum-seeking populations exhibit clinically significant sleep disturbances, with high pooled prevalence of sleep adversities.
A systematic review and meta-analysis of 66 studies (n=42,956) found that refugees and asylum seekers have clinically significant sleep disturbances. The pooled mean Insomnia Severity Index (ISI) score was 13.76 (95% CI 10.39-17.13), bordering on moderate clinical insomnia, and the pooled mean Pittsburgh Sleep Quality Index (PSQI) score was 8.59 (95% CI 2.11-15.07), exceeding clinical thresholds for poor sleep. The pooled prevalence of sleep adversities was 43.2% in adults and 36.4% in children.
Meta-analyses of the same intervention can yield conflicting results due to differences in inclusion criteria, statistical methods, and outcome definitions.
This paper examines why meta-analyses on the same topic may disagree, highlighting that pooled estimates can vary based on methodological choices. It emphasizes the need to look beyond the summary effect to understand sources of heterogeneity.
Full Cognitive Behavioral Therapy for Insomnia (CBT-I) improves work productivity outcomes including absenteeism and presenteeism in adults with insomnia.
Moderate-quality evidence from 7 randomized controlled trials involving 4751 participants showed that Full CBT-I significantly improved absenteeism and presenteeism. Low-quality evidence supported its effect on work productivity loss and activity impairment.
Long-term use of dual orexin receptor antagonists improves subjective sleep outcomes in adults with chronic insomnia
A systematic review and meta-analysis of 6 randomized controlled trials with 3,546 participants found that DORAs (suvorexant, lemborexant, daridorexant) improved subjective sleep parameters at 6 and 12 months. Adverse events were similar to placebo at 6 months but higher at 12 months, with no significant difference in overall discontinuation due to adverse events, though higher doses increased discontinuation at 6 months.
Newest Studies
All →Machine Learning-Based Prediction of Sleep Quality in Patients with Multiple Sclerosis.
Medical sciences (Basel, Switzerland), 2026 · observational
Comparing Respiratory Support Modalities in Pediatric Asthma Exacerbation-A Systematic Review and Meta-Analysis.
Pediatric reports, 2026 · meta
Digital health promotion, prevention and health literacy measures among seafarers and crews on cargo and passenger ships: A scoping review.
PloS one, 2026 · observational
Decreased accumbens-amygdala connectivity is associated with sleep improvement in late-life depression following mindfulness-based cognitive therapy.
Journal of affective disorders, 2026 · rct
Recently Updated
All →Insomnia induces intestinal microbiota disorder, and artificial interventions targeting gut microbiota can improve sleep.
This narrative review summarizes evidence that insomnia can disrupt intestinal microbiota by activating immune responses, the HPA axis, and neuroendocrine systems, while gut microbiota can exacerbate insomnia via neurotransmitter and inflammatory factor release. Artificial interventions such as probiotics, traditional Chinese medicine, fecal microbiota transplantation, diet, and exercise may improve sleep by affecting neurotransmitter and microbial metabolite release.
Melissa officinalis Phytosome (MOP) improves sleep quality in adults with mild insomnia
In a double-blind, placebo-controlled crossover study, MOP significantly reduced Insomnia Severity Index (ISI) scores by an average of 2.9 points compared to placebo (6.8 ± 4.1 vs 9.7 ± 3.7, p=0.003). Slow-wave sleep (SWS) duration increased by 15%, REM sleep decreased by 10%, and 87% of treated participants reported improved sleep quality versus 30% in the placebo group (χ²=21.01, p=0.0003).
Gut microbiota taxa are causally associated with insomnia risk in European ancestry individuals
A Mendelian randomization study identified that Enterorhabdus, Family XIII AD3011 group, Paraprevotella, and Lachnospiraceae UCG004 increase insomnia risk, while Coprococcus1, Coprobacter, Desulfovibrio, Flavonifractor, Olsenella, Odoribacter, and Oscillibacter decrease risk. For specific insomnia phenotypes, Eisenbergiella increased risk of trouble falling asleep, while Haemophilus and Eubacterium brachy group reduced it; Family XIII UCG001, Lachnospiraceae FCS020 group, and Olsenella increased risk of waking too early, while Eubacterium brachy group and Victivallis reduced it.
Six hub herb pairs (Radix Astragali-Radix et Rhizoma Ginseng, Rhizoma Chuanxiong-Radix Glycyrrhizae, Seman Platycladi-Semen Ziziphi Spinosae, Pericarpium Citri Reticulatae-Radix Glycyrrhizae, Radix Polygalae-Semen Ziziphi Spinosae, Radix Astragali-Semen Ziziphi Spinosae) may treat insomnia via the cAMP signaling pathway synergistically with HIF-1, prolactin, chemical carcinogenesis receptor activation, and PI3K-Akt signaling pathways.
This study analyzed 104 TCM prescriptions for insomnia using data mining, network pharmacology, and molecular docking. Six hub herb pairs were identified, and network pharmacology suggested they may act through the cAMP signaling pathway in synergy with four other pathways, with molecular docking showing good binding affinity between active ingredients and hub targets.
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